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pubmed: 0804-4643
Predicting the risk of Multiple Endocrine Neoplasia type 1 (MEN1) for patients with commonly occurring endocrine tumors.
de Laat JM, Tham E, Pieterman CR, Vriens MR, Dorresteijn JA, Bots ML, Nordenskjöld M, van der Luijt RB, Valk GD Predicting the risk of Multiple Endocrine Neoplasia type 1 (MEN1) for patients with commonly occurring endocrine tumors. Eur J Endocrinol. 2012 May 11; Authors: de Laat JM, Tham E, Pieterman CR, Vriens MR, Dorresteijn JA, Bots ML, Nordenskjöld M, van der Luijt RB, Valk GD Abstract ObjectiveEndocrine diseases that can be part of the rare inheritable syndrome Multiple Endocrine Neoplasia type 1 (MEN1) commonly occur in the general population. Patients at risk for MEN1, and consequently their families, must be identified to prevent morbidity through periodic screening for the detection and treatment of manifestations in an early stage. Aim of the study was to develop a model for predicting MEN1 in individual patients with sporadically occurring endocrine tumors.DesignCross-sectional study.MethodsIn a nationwide study in The Netherlands patients with sporadically occurring endocrine tumors of whom the referring physician suspected the MEN1 syndrome were identified between 1998 and 2010 (n=365). Logistic regression analysis with internal validation by using bootstrapping and external validation with a cohort from Sweden was used.ResultsA MEN1 mutation was found in 15.9% of 365 patients. Recurrent primary hyperparathyroidism (OR 162.40), non-recurrent primary hyperparathyroidism (OR 25.78), pancreatic and duodenal neuro-endocrine tumors (pNET) (OR 17.94), pituitary tumor (OR 4.71), NET of stomach, thymus or bronchus (OR 25.84), positive family history of NET (OR 4.53) and age (OR 0.96) predicted MEN1. The c-statistic of the prediction model was 0.86 (95% CI 0.81-0.90) in the derivation cohort and 0.77 (95% CI 0.66 -0.88) in the validation cohort.ConclusionWith the prediction model the risk of MEN1 can be calculated in patients suspected for MEN1 with sporadically occurring endocrine tumors. PMID: 22581216 [PubMed - as supplied by publisher]
Permanent Endocrinology Jobs
Endocrinology jobs
Thu, 17 May 2012 02:53:04 -0500
All Endocrinology jobs for Thu May 17 2012
Endocrinology jobs in "Fairfield" - CT
Wed, 16 May 2012 12:15:44 -0600
Job 94619 Join a premier Endocrinology group in highly desirable Fairfield County, CT, within an easy drive to New York City! Exceptional opportunity to continue to grow into the premier Endocrinology
Endocrinology jobs in "NEW YORK" - NY
Wed, 16 May 2012 12:15:44 -0600
Job 941947 3 hrs to New York City. Beautiful Finger Lakes Region. Practice located on Hospital Campus. 30 minutes from Cornell University. Building new Center for Excellence for Diabetes patients.
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pubmed: 0804-4643
Predicting the risk of Multiple Endocrine Neoplasia type 1 (MEN1) for patients with commonly occurring endocrine tumors.
de Laat JM, Tham E, Pieterman CR, Vriens MR, Dorresteijn JA, Bots ML, Nordenskjöld M, van der Luijt RB, Valk GD Predicting the risk of Multiple Endocrine Neoplasia type 1 (MEN1) for patients with commonly occurring endocrine tumors. Eur J Endocrinol. 2012 May 11; Authors: de Laat JM, Tham E, Pieterman CR, Vriens MR, Dorresteijn JA, Bots ML, Nordenskjöld M, van der Luijt RB, Valk GD Abstract ObjectiveEndocrine diseases that can be part of the rare inheritable syndrome Multiple Endocrine Neoplasia type 1 (MEN1) commonly occur in the general population. Patients at risk for MEN1, and consequently their families, must be identified to prevent morbidity through periodic screening for the detection and treatment of manifestations in an early stage. Aim of the study was to develop a model for predicting MEN1 in individual patients with sporadically occurring endocrine tumors.DesignCross-sectional study.MethodsIn a nationwide study in The Netherlands patients with sporadically occurring endocrine tumors of whom the referring physician suspected the MEN1 syndrome were identified between 1998 and 2010 (n=365). Logistic regression analysis with internal validation by using bootstrapping and external validation with a cohort from Sweden was used.ResultsA MEN1 mutation was found in 15.9% of 365 patients. Recurrent primary hyperparathyroidism (OR 162.40), non-recurrent primary hyperparathyroidism (OR 25.78), pancreatic and duodenal neuro-endocrine tumors (pNET) (OR 17.94), pituitary tumor (OR 4.71), NET of stomach, thymus or bronchus (OR 25.84), positive family history of NET (OR 4.53) and age (OR 0.96) predicted MEN1. The c-statistic of the prediction model was 0.86 (95% CI 0.81-0.90) in the derivation cohort and 0.77 (95% CI 0.66 -0.88) in the validation cohort.ConclusionWith the prediction model the risk of MEN1 can be calculated in patients suspected for MEN1 with sporadically occurring endocrine tumors. PMID: 22581216 [PubMed - as supplied by publisher]
Permanent Endocrinology Jobs
Endocrinology jobs
Thu, 17 May 2012 02:53:04 -0500
All Endocrinology jobs for Thu May 17 2012
Endocrinology jobs in "Fairfield" - CT
Wed, 16 May 2012 12:15:44 -0600
Job 94619 Join a premier Endocrinology group in highly desirable Fairfield County, CT, within an easy drive to New York City! Exceptional opportunity to continue to grow into the premier Endocrinology
Endocrinology jobs in "NEW YORK" - NY
Wed, 16 May 2012 12:15:44 -0600
Job 941947 3 hrs to New York City. Beautiful Finger Lakes Region. Practice located on Hospital Campus. 30 minutes from Cornell University. Building new Center for Excellence for Diabetes patients.
Sites:
Diabetes Physicians: Find a Portland doctor in the OHSU Medical Group. Find a Doctor by name, health condition or specialty.Endocrine Surgeon: EndocrineSurgeon.co.uk - the Endocrine Surgery web site, focusing on problems with the thyroid, parathyroid and adrenal glands
EndocrineWeb: Large award winning site written by doctors and patients FOR PATIENTS. Over 200 pages and illustrations for thyroid, parathyroid and adrenal. Find a local doctor, support group or join the chat rooms. Updated daily, includes the newest treatments; new pages weekly.
Endocrinology Section - University of Chicago: Information on endocrine disorders and diseases from the highly esteemed Endocrinology Section at the University of Chicago Medical Center.
Endocrinology.com: A site dedicated to the study of Endocrinology
EndoLinx: Features peer-reviewed endocrinology articles, news, newsletters, CME, conferences, and medical dictionaries. EndoLinx and MDLinx aggregate for physicians, health care professionals, residents, med students the most current medical news, journals, and research.
Family Practice Notebook - Endocrinology: Contains Adrenal Disease, Diabetes Mellitus, Examination, Growth, Hypoglycemia, Metabolism, Obesity, Parathyroid Disease, Pituitary Disease, Sex, Symptom Evaluation and Thyroid Disease. Related chapters from other specialties include Dermatology, Ophthalmology, Geriatric, Hematology and Oncology...
Medscape: Diabetes and Endocrinology: Medscape Diabetes and Endocrinology is a free resource for Physicians, featuring Free Diabetes and Endocrinology CME (Continuing Medical Education), Diabetes and Endocrinology medical journal articles, MEDLINE, Diabetes and Endocrinology medical news, major Diabetes and Endocrinology conference c...
National Diabetes Education Initiative: National Diabetes Education Initiative - Slides, Online CME, Events and Literature Alerts.
Online Endocrinology Journals: Free full-text access to Endocrine-Related Cancer, free access to reviews and commentaries and searchable advance abstracts from the Journal of Endocrinology and the Journal of Molecular Endocrinology.
ThyroidToday: Provides information on the causes, diagnosis, latest findings, and treatment of various forms of the disease.
UCLA Pituitary Tumor and Neuroendocrine Program: The UCLA Pituitary Tumor and Neuroendocrine Program directed by Dr. Daniel F. Kelly provides comprehensive evaluation and treatment of patients with pituitary tumors and related neuroendocrine disorders.
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