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transplant surgery - Google News
Hospital rapped for transplant violation - Times of India
Thu, 17 May 2012 22:57:08 -0000
Hospital rapped for transplant violationTimes of IndiaSenior health department officials said transplant surgeons at Apollo Hospitals had used a part of the liver received through the state cadaver registry for a patient from Mauritius despite several Indians being waitlisted for the surgery at the time.and more »
NJ Heart Transplant Specialist to Be Honored by Executive Women's Group - NJ Spotlight
Fri, 18 May 2012 04:55:36 -0000
NJ Heart Transplant Specialist to Be Honored by Executive Women's GroupNJ SpotlightMore than 300 transplants in past 20 years make Dr. Margarita Camacho one of the leading specialists in the nation. By Beth Fitzgerald, May 18, 2012 in Healthcare | Dr. Margarita Camacho, a surgeon at Newark Beth Israel Medical Center, ...
Wells woman calls her liver transplant 'a total miracle' - Seacoastonline.com
Thu, 17 May 2012 06:06:42 -0000
Wells woman calls her liver transplant 'a total miracle'Seacoastonline.comMischa DeMuth Winters says goodbye to his wife, Katie, as the Massachusetts General Hospital transplant team calls him in for surgery. He donated 60 percent of his liver to his mother, Jodi DeMuth, at left.Deb Cram photo By Jennifer Feals WELLS, ...Wells mom recovering after liver transplantYork County Coast Starall 2 news articles »
Life-changing decision - Hattiesburg American
Fri, 18 May 2012 05:32:00 -0000
Life-changing decisionHattiesburg AmericanMegan, who lives in Hattiesburg, and Elizabeth, who lives in Sumrall, had their surgery at the Ochsner Multi-Organ Transplant Institute in New Orleans on March 12. "I was diagnosed with lupus when I was 15," said Megan. "It was under control for most ...
Webster resident Bob Schmidt says he feels like 'the luckiest man alive' - Henrietta Post
Fri, 18 May 2012 01:10:20 -0000
Webster resident Bob Schmidt says he feels like 'the luckiest man alive'Henrietta PostUniversity of Rochester Medical Center cardiac transplant surgeons performed their 150th heart transplant, providing a second lease on life for Schmidt, March 23. “Right now, I feel like the luckiest guy in the world,” Schmidt said at his Webster home ...and more »
Pancreatic islets infusion for diabetes patient being readied for procedure in ... - Medical Xpress
Wed, 16 May 2012 22:57:47 -0000
Pancreatic islets infusion for diabetes patient being readied for procedure in ...Medical XpressThe Japanese Pancreas and Islet Transplantation Association (JPITA) is preparing for the nation's first transplantation of pancreatic islets from a brain-dead donor to a patient with Type 1 diabetes, it was learned Saturday. The preparation has been ...and more »
First hair transplant surgery conducted at GMSH-16 - Indian Express
Tue, 15 May 2012 01:56:30 -0000
First hair transplant surgery conducted at GMSH-16Indian ExpressIn A first, the Government Multi-Specialty Hospital, Sector 16, has recently successfully conducted a hair transplant surgery on a 32-year-old patient. Interestingly, Dr Chandesh Mahindroo, who is an ENT surgeon at the hospital, performed the surgery ...
StemCells, Inc. Reports Positive Interim Safety Data From Spinal Cord Injury Trial - MarketWatch (press release)
Thu, 17 May 2012 13:03:11 -0000
StemCells, Inc. Reports Positive Interim Safety Data From Spinal Cord Injury TrialMarketWatch (press release)Patients will be evaluated regularly in the post-transplant period in order to monitor and assess the safety of the HuCNS-SC cells, the surgery and the immunosuppression, as well as to measure any recovery of neurological function below the injury site ...and more »
Damonte Wood may need heart transplant after tackle by security guard - KSDK
Fri, 18 May 2012 03:09:49 -0000
KSDKDamonte Wood may need heart transplant after tackle by security guardKSDK... now need a heart transplant. On October 21, 2011, just after 8 am, Damontae Woods' grandmother dropped him off at Normandy High School. Forty minutes later, an ambulance rushed the 18-year-old junior to Children's Hospital for open heart surgery.and more »
pubmed: 0041-1345
0041-1345; +101 new citations
pubmed Thu, 17 May 2012 07:43:58 -0000
101 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: 0041-1345 These pubmed results were generated on 2012/05/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
pubmed: 1053-2498
Heart transplant recipient selection issues: Limited assets, infinite possibilities.
Hunt SA Heart transplant recipient selection issues: Limited assets, infinite possibilities. J Heart Lung Transplant. 2012 May 8; Authors: Hunt SA PMID: 22576058 [PubMed - as supplied by publisher]
Use of height and a novel echocardiographic measurement to improve size-matching for pediatric heart transplantation.
Zuckerman WA, Richmond ME, Singh RK, Chen JM, Addonizio LJ Use of height and a novel echocardiographic measurement to improve size-matching for pediatric heart transplantation. J Heart Lung Transplant. 2012 May 4; Authors: Zuckerman WA, Richmond ME, Singh RK, Chen JM, Addonizio LJ Abstract BACKGROUND: A major limitation of pediatric heart transplantation is scarcity of pediatric donor organs, leading to longer waiting times and higher waiting list mortality. Current practice is to match potential pediatric recipients with donors by weight; however, we hypothesize height to be a better predictor of heart size as estimated by left ventricular end-diastolic diameter (LVEDd), as well as a novel measurement from the superior vena cava-right atrium junction to inferior vena cava-right atrium junction (SVC-IVC distance). Our ultimate objective is to present a more effective means of size-matching for pediatric heart transplantation. METHODS: Measurements of LVEDd and SVC-IVC distance were taken from 254 normal echocardiograms performed on individuals aged 7 days to 22 years, and correlated with demographic variables, including height, weight, and body surface area. Simulations were conducted using echocardiographic measurements and size parameters of past recipients with hypothetic donors to demonstrate practicality. RESULTS: There was a linear relationship between height and SVC-IVC distance (R(2) = 0.904) and LVEDd (R(2) = 0.889), whereas the relationships with weight were logarithmic (SVC-IVC distance, R(2) = 0.855; LVEDd, R(2) = 0.880), and the relationships with body surface area were polynomial (SVC-IVC distance, R(2) = 0.880; LVEDd, R(2) = 0.884). Three simulations demonstrate improvements in efficiency of the size-matching process. CONCLUSIONS: The use of height and a novel SVC-IVC distance measurement to evaluate heart size in potential pediatric heart transplant recipients and donors may allow for broadening of the donor pool and creation of a more efficient and accurate size-matching process. The prospective evaluation of these novel methods with respect to clinical outcomes is necessary. PMID: 22560083 [PubMed - as supplied by publisher]
Cyclosporine immunosuppression does not prevent the production of donor-specific antibody capable of mediating allograft vasculopathy.
Gareau AJ, Nashan B, Hirsch GM, Lee TD Cyclosporine immunosuppression does not prevent the production of donor-specific antibody capable of mediating allograft vasculopathy. J Heart Lung Transplant. 2012 May 2; Authors: Gareau AJ, Nashan B, Hirsch GM, Lee TD Abstract BACKGROUND: Late cardiac graft rejection, primarily mediated by allograft vasculopathy (AV), remains a major limitation to cardiac transplantation, even in the face of significant calcineurin inhibitor (CNI) immunosuppression. The role played by alloantibody in AV is unclear. Evidence that CNI immunosuppression suppresses CD4(+) T-cell function would suggest that antibody production and effector function would be severely limited in CNI-treated patients. In this study we examine the capacity of CNI-treated animals to develop effective alloantibody that can mediate AV. METHODS: Wild-type (WT) B6 mice were alloimmunized using donor splenocytes or a fully major histocompatibility complex-mismatched allogeneic abdominal aortic graft in the presence of CNI immunosuppression (30 or 50 mg/kg/day cyclosporine A). Anti-serum was harvested and tested using complement-dependent in vitro cytotoxicity assays. Anti-serum was passively transferred to immunodeficient RAG1(-/-) recipients of allogeneic grafts. C4d deposition was quantified in the allografts from WT recipients. RESULTS: CNI immunosuppression did not prevent the development of alloantibody in response to either immunization method (p < 0.05). Passive transfer of anti-serum generated AV lesions in immunodeficient graft recipients and mediated complement-dependent destruction of donor cells (p < 0.05). C4d deposition was localized to the media of grafts of CNI treated animals. CONCLUSIONS: CNI therapy does not prevent the production of alloantibody with the capacity to mediate AV. C4d deposition in the media suggests a role for medial smooth muscle cell loss in antibody-mediated AV lesion development in our model. PMID: 22554675 [PubMed - as supplied by publisher]
High incidence of unexpected defibrillation coil retention during orthotopic heart transplantation.
Abraham P, Caliskan K, Szili-Torok T High incidence of unexpected defibrillation coil retention during orthotopic heart transplantation. J Heart Lung Transplant. 2012 May 2; Authors: Abraham P, Caliskan K, Szili-Torok T PMID: 22554674 [PubMed - as supplied by publisher]
Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation.
Treede H, Glanville AR, Klepetko W, Aboyoun C, Vettorazzi E, Lama R, Bravo C, Knoop C, Aubert JD, Reichenspurner H, Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation. J Heart Lung Transplant. 2012 May 2; Authors: Treede H, Glanville AR, Klepetko W, Aboyoun C, Vettorazzi E, Lama R, Bravo C, Knoop C, Aubert JD, Reichenspurner H, Abstract BACKGROUND: Chronic lung allograft dysfunction, which manifests as bronchiolitis obliterans syndrome (BOS), is recognized as the primary cause of morbidity and mortality after lung transplantation. In this study we assessed the efficacy and safety of two de novo immunosuppression protocols to prevent BOS. METHODS: Our study approach was a multicenter, prospective, randomized (1:1) open-label superiority investigation of de novo tacrolimus vs cyclosporine, with both study arms given mycophenolate mofetil and prednisolone after lung transplantation. Cytolytic induction therapy was not employed. Patients were stratified at entry for cystic fibrosis. Primary outcome was incidence of BOS 3 years after transplant (intention-to-treat analysis). Secondary outcomes were survival and incidence of acute rejection, infection and other adverse events. RESULTS: Group demographic data were well matched: 110 of 124 tacrolimus vs 74 of 125 cyclosporine patients were treated per protocol (p < 0.01 by chi-square test). Cumulative incidence of BOS Grade ≥1 at 3 years was 11.6% (tacrolimus) vs 21.3% (cyclosporine) (cumulative incidence curves, p = 0.037 by Gray's test, pooled over strata). Univariate proportional sub-distribution hazards regression confirmed cyclosporine as a risk for BOS (HR 1.97, 95% CI 1.04 to 3.77, p = 0.039). Three-year cumulative incidence of acute rejection was 67.4% (tacrolimus) vs 74.9% (cyclosporine) (p = 0.118 by Gray's test). One- and 3-year survival rates were 84.6% and 78.7% (tacrolimus) vs 88.6% and 82.8% (cyclosporine) (p = 0.382 by log-rank test). Cumulative infection rates were similar (p = 0.91), but there was a trend toward new-onset renal failure with tacrolimus (p = 0.09). CONCLUSIONS: Compared with cyclosporine, de novo tacrolimus use was found to be associated with a significantly reduced risk for BOS Grade ≥1 at 3 years despite a similar rate of acute rejection. However, no survival advantage was detected. PMID: 22554673 [PubMed - as supplied by publisher]
Outcomes of cardiac transplantation in septuagenarians.
Goldstein DJ, Bello R, Shin JJ, Stevens G, Zolty R, Maybaum S, D'Alessandro D Outcomes of cardiac transplantation in septuagenarians. J Heart Lung Transplant. 2012 May 2; Authors: Goldstein DJ, Bello R, Shin JJ, Stevens G, Zolty R, Maybaum S, D'Alessandro D Abstract BACKGROUND: Cardiac transplantation in many centers is programmatically limited to patients aged younger than 70 years. We investigated the trends and outcomes for cardiac transplantation in recipients aged 70 years and older in the United States. METHODS: De-identified data were provided by United Network of Organ Sharing. Transplant recipients were grouped by age 60-69 years and 70 years and older. Univariate comparisons were performed using Student's t-test or the Pearson chi-square test. Survival was estimated using the Kaplan-Meier technique and compared with the log-rank test. Cox regression was used to determine predictors of death after transplant. Statistical significance was assigned to p < 0.05. RESULTS: Between January 1, 1998, and June 15, 2010, 5,807 sexagenarians and 332 septuagenarians received allografts. The septuagenarian cohort had more men, less diabetes, was less likely to have a ventricular assist device, and more likely to be status II. Donors for septuagenarians were older and died more frequently from intracranial hemorrhage. Median unadjusted survival was 9.8 years for sexagenarians vs 8.5 years for septuagenarians (p = 0.003). There was no difference in the incidence of cerebrovascular accident, length of stay, or pacemaker need between groups. Septuagenarians were less likely to be treated for rejection the first year (p = 0.001). Age was a multivariate predictor of death (hazard ratio, 1.289; 95% confidence interval, 1.039-1.6; p = 0.021). CONCLUSIONS: Selected septuagenarians with advanced heart failure can derive great benefit from cardiac transplantation, although survival is inferior to that of an immediately younger sexagenarian cohort. Most of the mortality risk is seen in the first year after transplantation. A reduced incidence of rejection was observed and warrants further study. PMID: 22554672 [PubMed - as supplied by publisher]
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Hospital rapped for transplant violation - Times of India
Thu, 17 May 2012 22:57:08 -0000
Hospital rapped for transplant violationTimes of IndiaSenior health department officials said transplant surgeons at Apollo Hospitals had used a part of the liver received through the state cadaver registry for a patient from Mauritius despite several Indians being waitlisted for the surgery at the time.and more »
NJ Heart Transplant Specialist to Be Honored by Executive Women's Group - NJ Spotlight
Fri, 18 May 2012 04:55:36 -0000
NJ Heart Transplant Specialist to Be Honored by Executive Women's GroupNJ SpotlightMore than 300 transplants in past 20 years make Dr. Margarita Camacho one of the leading specialists in the nation. By Beth Fitzgerald, May 18, 2012 in Healthcare | Dr. Margarita Camacho, a surgeon at Newark Beth Israel Medical Center, ...
Wells woman calls her liver transplant 'a total miracle' - Seacoastonline.com
Thu, 17 May 2012 06:06:42 -0000
Wells woman calls her liver transplant 'a total miracle'Seacoastonline.comMischa DeMuth Winters says goodbye to his wife, Katie, as the Massachusetts General Hospital transplant team calls him in for surgery. He donated 60 percent of his liver to his mother, Jodi DeMuth, at left.Deb Cram photo By Jennifer Feals WELLS, ...Wells mom recovering after liver transplantYork County Coast Starall 2 news articles »
Life-changing decision - Hattiesburg American
Fri, 18 May 2012 05:32:00 -0000
Life-changing decisionHattiesburg AmericanMegan, who lives in Hattiesburg, and Elizabeth, who lives in Sumrall, had their surgery at the Ochsner Multi-Organ Transplant Institute in New Orleans on March 12. "I was diagnosed with lupus when I was 15," said Megan. "It was under control for most ...
Webster resident Bob Schmidt says he feels like 'the luckiest man alive' - Henrietta Post
Fri, 18 May 2012 01:10:20 -0000
Webster resident Bob Schmidt says he feels like 'the luckiest man alive'Henrietta PostUniversity of Rochester Medical Center cardiac transplant surgeons performed their 150th heart transplant, providing a second lease on life for Schmidt, March 23. “Right now, I feel like the luckiest guy in the world,” Schmidt said at his Webster home ...and more »
Pancreatic islets infusion for diabetes patient being readied for procedure in ... - Medical Xpress
Wed, 16 May 2012 22:57:47 -0000
Pancreatic islets infusion for diabetes patient being readied for procedure in ...Medical XpressThe Japanese Pancreas and Islet Transplantation Association (JPITA) is preparing for the nation's first transplantation of pancreatic islets from a brain-dead donor to a patient with Type 1 diabetes, it was learned Saturday. The preparation has been ...and more »
First hair transplant surgery conducted at GMSH-16 - Indian Express
Tue, 15 May 2012 01:56:30 -0000
First hair transplant surgery conducted at GMSH-16Indian ExpressIn A first, the Government Multi-Specialty Hospital, Sector 16, has recently successfully conducted a hair transplant surgery on a 32-year-old patient. Interestingly, Dr Chandesh Mahindroo, who is an ENT surgeon at the hospital, performed the surgery ...
StemCells, Inc. Reports Positive Interim Safety Data From Spinal Cord Injury Trial - MarketWatch (press release)
Thu, 17 May 2012 13:03:11 -0000
StemCells, Inc. Reports Positive Interim Safety Data From Spinal Cord Injury TrialMarketWatch (press release)Patients will be evaluated regularly in the post-transplant period in order to monitor and assess the safety of the HuCNS-SC cells, the surgery and the immunosuppression, as well as to measure any recovery of neurological function below the injury site ...and more »
Damonte Wood may need heart transplant after tackle by security guard - KSDK
Fri, 18 May 2012 03:09:49 -0000
KSDKDamonte Wood may need heart transplant after tackle by security guardKSDK... now need a heart transplant. On October 21, 2011, just after 8 am, Damontae Woods' grandmother dropped him off at Normandy High School. Forty minutes later, an ambulance rushed the 18-year-old junior to Children's Hospital for open heart surgery.and more »
pubmed: 0041-1345
0041-1345; +101 new citations
pubmed Thu, 17 May 2012 07:43:58 -0000
101 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: 0041-1345 These pubmed results were generated on 2012/05/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
pubmed: 1053-2498
Heart transplant recipient selection issues: Limited assets, infinite possibilities.
Hunt SA Heart transplant recipient selection issues: Limited assets, infinite possibilities. J Heart Lung Transplant. 2012 May 8; Authors: Hunt SA PMID: 22576058 [PubMed - as supplied by publisher]
Use of height and a novel echocardiographic measurement to improve size-matching for pediatric heart transplantation.
Zuckerman WA, Richmond ME, Singh RK, Chen JM, Addonizio LJ Use of height and a novel echocardiographic measurement to improve size-matching for pediatric heart transplantation. J Heart Lung Transplant. 2012 May 4; Authors: Zuckerman WA, Richmond ME, Singh RK, Chen JM, Addonizio LJ Abstract BACKGROUND: A major limitation of pediatric heart transplantation is scarcity of pediatric donor organs, leading to longer waiting times and higher waiting list mortality. Current practice is to match potential pediatric recipients with donors by weight; however, we hypothesize height to be a better predictor of heart size as estimated by left ventricular end-diastolic diameter (LVEDd), as well as a novel measurement from the superior vena cava-right atrium junction to inferior vena cava-right atrium junction (SVC-IVC distance). Our ultimate objective is to present a more effective means of size-matching for pediatric heart transplantation. METHODS: Measurements of LVEDd and SVC-IVC distance were taken from 254 normal echocardiograms performed on individuals aged 7 days to 22 years, and correlated with demographic variables, including height, weight, and body surface area. Simulations were conducted using echocardiographic measurements and size parameters of past recipients with hypothetic donors to demonstrate practicality. RESULTS: There was a linear relationship between height and SVC-IVC distance (R(2) = 0.904) and LVEDd (R(2) = 0.889), whereas the relationships with weight were logarithmic (SVC-IVC distance, R(2) = 0.855; LVEDd, R(2) = 0.880), and the relationships with body surface area were polynomial (SVC-IVC distance, R(2) = 0.880; LVEDd, R(2) = 0.884). Three simulations demonstrate improvements in efficiency of the size-matching process. CONCLUSIONS: The use of height and a novel SVC-IVC distance measurement to evaluate heart size in potential pediatric heart transplant recipients and donors may allow for broadening of the donor pool and creation of a more efficient and accurate size-matching process. The prospective evaluation of these novel methods with respect to clinical outcomes is necessary. PMID: 22560083 [PubMed - as supplied by publisher]
Cyclosporine immunosuppression does not prevent the production of donor-specific antibody capable of mediating allograft vasculopathy.
Gareau AJ, Nashan B, Hirsch GM, Lee TD Cyclosporine immunosuppression does not prevent the production of donor-specific antibody capable of mediating allograft vasculopathy. J Heart Lung Transplant. 2012 May 2; Authors: Gareau AJ, Nashan B, Hirsch GM, Lee TD Abstract BACKGROUND: Late cardiac graft rejection, primarily mediated by allograft vasculopathy (AV), remains a major limitation to cardiac transplantation, even in the face of significant calcineurin inhibitor (CNI) immunosuppression. The role played by alloantibody in AV is unclear. Evidence that CNI immunosuppression suppresses CD4(+) T-cell function would suggest that antibody production and effector function would be severely limited in CNI-treated patients. In this study we examine the capacity of CNI-treated animals to develop effective alloantibody that can mediate AV. METHODS: Wild-type (WT) B6 mice were alloimmunized using donor splenocytes or a fully major histocompatibility complex-mismatched allogeneic abdominal aortic graft in the presence of CNI immunosuppression (30 or 50 mg/kg/day cyclosporine A). Anti-serum was harvested and tested using complement-dependent in vitro cytotoxicity assays. Anti-serum was passively transferred to immunodeficient RAG1(-/-) recipients of allogeneic grafts. C4d deposition was quantified in the allografts from WT recipients. RESULTS: CNI immunosuppression did not prevent the development of alloantibody in response to either immunization method (p < 0.05). Passive transfer of anti-serum generated AV lesions in immunodeficient graft recipients and mediated complement-dependent destruction of donor cells (p < 0.05). C4d deposition was localized to the media of grafts of CNI treated animals. CONCLUSIONS: CNI therapy does not prevent the production of alloantibody with the capacity to mediate AV. C4d deposition in the media suggests a role for medial smooth muscle cell loss in antibody-mediated AV lesion development in our model. PMID: 22554675 [PubMed - as supplied by publisher]
High incidence of unexpected defibrillation coil retention during orthotopic heart transplantation.
Abraham P, Caliskan K, Szili-Torok T High incidence of unexpected defibrillation coil retention during orthotopic heart transplantation. J Heart Lung Transplant. 2012 May 2; Authors: Abraham P, Caliskan K, Szili-Torok T PMID: 22554674 [PubMed - as supplied by publisher]
Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation.
Treede H, Glanville AR, Klepetko W, Aboyoun C, Vettorazzi E, Lama R, Bravo C, Knoop C, Aubert JD, Reichenspurner H, Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation. J Heart Lung Transplant. 2012 May 2; Authors: Treede H, Glanville AR, Klepetko W, Aboyoun C, Vettorazzi E, Lama R, Bravo C, Knoop C, Aubert JD, Reichenspurner H, Abstract BACKGROUND: Chronic lung allograft dysfunction, which manifests as bronchiolitis obliterans syndrome (BOS), is recognized as the primary cause of morbidity and mortality after lung transplantation. In this study we assessed the efficacy and safety of two de novo immunosuppression protocols to prevent BOS. METHODS: Our study approach was a multicenter, prospective, randomized (1:1) open-label superiority investigation of de novo tacrolimus vs cyclosporine, with both study arms given mycophenolate mofetil and prednisolone after lung transplantation. Cytolytic induction therapy was not employed. Patients were stratified at entry for cystic fibrosis. Primary outcome was incidence of BOS 3 years after transplant (intention-to-treat analysis). Secondary outcomes were survival and incidence of acute rejection, infection and other adverse events. RESULTS: Group demographic data were well matched: 110 of 124 tacrolimus vs 74 of 125 cyclosporine patients were treated per protocol (p < 0.01 by chi-square test). Cumulative incidence of BOS Grade ≥1 at 3 years was 11.6% (tacrolimus) vs 21.3% (cyclosporine) (cumulative incidence curves, p = 0.037 by Gray's test, pooled over strata). Univariate proportional sub-distribution hazards regression confirmed cyclosporine as a risk for BOS (HR 1.97, 95% CI 1.04 to 3.77, p = 0.039). Three-year cumulative incidence of acute rejection was 67.4% (tacrolimus) vs 74.9% (cyclosporine) (p = 0.118 by Gray's test). One- and 3-year survival rates were 84.6% and 78.7% (tacrolimus) vs 88.6% and 82.8% (cyclosporine) (p = 0.382 by log-rank test). Cumulative infection rates were similar (p = 0.91), but there was a trend toward new-onset renal failure with tacrolimus (p = 0.09). CONCLUSIONS: Compared with cyclosporine, de novo tacrolimus use was found to be associated with a significantly reduced risk for BOS Grade ≥1 at 3 years despite a similar rate of acute rejection. However, no survival advantage was detected. PMID: 22554673 [PubMed - as supplied by publisher]
Outcomes of cardiac transplantation in septuagenarians.
Goldstein DJ, Bello R, Shin JJ, Stevens G, Zolty R, Maybaum S, D'Alessandro D Outcomes of cardiac transplantation in septuagenarians. J Heart Lung Transplant. 2012 May 2; Authors: Goldstein DJ, Bello R, Shin JJ, Stevens G, Zolty R, Maybaum S, D'Alessandro D Abstract BACKGROUND: Cardiac transplantation in many centers is programmatically limited to patients aged younger than 70 years. We investigated the trends and outcomes for cardiac transplantation in recipients aged 70 years and older in the United States. METHODS: De-identified data were provided by United Network of Organ Sharing. Transplant recipients were grouped by age 60-69 years and 70 years and older. Univariate comparisons were performed using Student's t-test or the Pearson chi-square test. Survival was estimated using the Kaplan-Meier technique and compared with the log-rank test. Cox regression was used to determine predictors of death after transplant. Statistical significance was assigned to p < 0.05. RESULTS: Between January 1, 1998, and June 15, 2010, 5,807 sexagenarians and 332 septuagenarians received allografts. The septuagenarian cohort had more men, less diabetes, was less likely to have a ventricular assist device, and more likely to be status II. Donors for septuagenarians were older and died more frequently from intracranial hemorrhage. Median unadjusted survival was 9.8 years for sexagenarians vs 8.5 years for septuagenarians (p = 0.003). There was no difference in the incidence of cerebrovascular accident, length of stay, or pacemaker need between groups. Septuagenarians were less likely to be treated for rejection the first year (p = 0.001). Age was a multivariate predictor of death (hazard ratio, 1.289; 95% confidence interval, 1.039-1.6; p = 0.021). CONCLUSIONS: Selected septuagenarians with advanced heart failure can derive great benefit from cardiac transplantation, although survival is inferior to that of an immediately younger sexagenarian cohort. Most of the mortality risk is seen in the first year after transplantation. A reduced incidence of rejection was observed and warrants further study. PMID: 22554672 [PubMed - as supplied by publisher]
Sites:
Pancreas Transplant: California Pacific Medical Center - Kidney and kidney-pancreas transplant programAmerican Society of Transplant Surgeons: The coordination of efforts or formulation of programs by surgeons, physicians, scientists, agencies and health personnel to provide maximal efficiency and optimal benefit to recipients of transplants.
Bio Implant Services(BIS) Foundation: A non-profit organization, that mediates in the donation and allocation of human tissue for transplantation purposes.
CenterSpan: CenterSpan - Your comprehensive source of transplant information
Charles O. Strickler Transplant Center: UVa Charles O. Strickler Center Transplant Program is one of the finest transplant programs available.
CTS Collaborative Transplant Study: CTS is an international study in the field of transplantation research and provides with information on resources and literature
Division of Transplantation Pathology: Provide up-to-date laboratory services with expertise in pathology, immunology and molecular biology. Actively involved in many transplantation related research projects.
Donor Alliance, Inc.: Donor Alliance, Inc. is a nonprofit organization that facilitates the recovery and donation of organs and tissues in Colorado and Wyoming.
Emory University Hospital: An overview of the academic, clinical, and investigative components of the Division of Transplantation of the Department of Surgery, Emory University School of Medicine
Eurotransplant: Eurotransplant Website
High Complexity Assistance: Columbian network of clinics and hospitals offering organ transplant to foreign patients.
Iowa Donor Network (IDN): Iowa Donor Network Home Page., Iowa Donor Network (IDN) is the federally mandated organ procurement organization for Iowa. IDN runs the state's only organ and tissue donor registry.
Johns Hopkins Comprehensive Transplant Center: The Johns Hopkins Comprehensive Transplant Center is one of only a few centers nationwide to offer a comprehensive array of transplantation services for adult and pediatric patients.
LifeLink Foundation: LifeLink Foundation - Organ and Tissue Transplant Therapy, Florida, Georgia, Puerto Rico. Providing information about organ and tissue donation and transplantation.
LifeNet: A non-profit organ procurement organization providing donation systems for heart, liver, kidney, pancreas, lung, and other organs for transplant.
Mary Lea Johnson Richards Transplant Center at NYU Hospitals Center: The Mary Lea Johnson Richards Organ Transplantation Center at NYU Hospitals Center offers a variety of services including liver transplantation, living donor liver transplantation, kidney transplantation, living donor kidney transplantation, laparoscopic kidney transplantation, kidney-pancreas tr...
Mayo Clinic Transplant Center: Organ Transplant at Mayo Clinic: Transplant programs and specialties including heart, liver, lung, and bone marrow transplants.
Medical College of Virginia Hospitals of the VCU Health System Transplant Center: Contains information for patients and referring physicians about the transplant services available at MCVH/VCUHS, including liver, kidney, and kidney-pancreas transplant, as well as laparoscopic living kidney and living liver donation.
Medical College of Wisconsin: MCW HealthLink articles on Transplants/Organ Donations
New England Organ Bank: AllWebCo Website Templates and Pre-Made Websites. Very reasonable prices and a complete setup.
Oregon Health Sciences University Transplant Program: Oregon Health & Science University has one of the longest-established transplant centers in the world, with excellent outcomes.
Organ and Tissue Donation Initiative: Official Organ Donation and Transplantation Web site of the U.S. Department of Health and Human Services
Pacific Northwest Transplant Bank: The Pacific NW Transplant Bank provides organ recovery services to Oregon, southern Washington and SW Idaho
St. Vincent Medical Center: Multi-organ transplantation, cardiac care, ancillary health services, cancer research and treatment.
The Nicholas Green Foundation: A non-profit organization dedicated to furthering the cause of organ and tissue donation around the world.
The Recanati/Miller Transplantation Institute at Mount Sinai, NY: The Recanati/Miller Transplantation Institute comprises world-renowned physicians, surgeons, and scientists in a wide variety of organ transplant and medical specialties.
The Transplant Center at Fairview-University Medical Center: The Transplant Center, A Unique Partnership of University of Minnesota Physicians Transplant Program and Fairview Health Services offering heart, intestinal, kidney, liver, lung, pancreas and islet transplantation services.
TissueNet.Com: TissueNet works with hospital chains who want to reduce their cost of Allograft Tissue. Our large consolidation of Tissue Banks offer a greater availability which reduces Allograft Tissue costs and saves time in acquiring these Allografts for surgery.>
Transplant Center Berlin-Steglitz, Germany: Kidney transplantation at UKBF Berlin, Germany. Complete English and German version. Medical and public information on transplantation and organ donation.
Transplant Pathology Internet Services: International collaboration and standardization of criteria in assessing histopathologic features of rejection.
Transplant Week -- Your Online Transplant Newsletter: Transplant Week - Online news about organ transplants, transplantation and transplant donations. Updated daily, with information on developments in transplant research, answers to patient questions, resources and links.
Transplantation: Provides access to the official journal of the Transplantation Society.
TransplantFinder.com: A free web resource for locating approved renal transplant center. Provides addresses, maps, web sites, phone numbers and fax numbers to kidney transplant centers.
UHN Toronto General Hospital: Offering a multi organ transplant services in Canada.
University of Maryland Transplant Center: Organ transplant services at the UMMC Division of Transplantation. We are a comprehensive center with transplantation capabilities in kidney, pancreas, simultaneous kidney-pancreas, liver, heart and lung, and perform more kidney transplants than any other
University of Nebraska Medical Center: The Nebraska Medical Center is home to one of the most reputable and well-known organ transplant programs in the country. Through our dedicated efforts in education, research and clinical medicine, we have helped shape the field of transplantation. We have a comprehensive Organ Transplant Program...
UWHC OPO: Organ procurement organization of the University of Wisconsin Hospitals and Clinics providing services to Wisconsin, Michigan and Illinois.
This directory is based on the Open Directory and may have been modified