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Permanent Urology Job in Corpus Christi, Texas Texas with Enterprise Medical Services
Due to continued growth of the area, a hospital system is planning to help start a new Urology practice with 1 and possibly 2 providers. Patient population in this area approaches 400,000. Position can
Permanent Urology Job in Live and work in Southern Illinois Illinois with Enterprise Medical Services
Opportunity for an Urologist in Southern Illinois. Physician can join with another Urologist or have a hospital sponsored solo position. Call coverage is 1:3. Medical loan assistance available. Signing
Permanent Urology Job in An excellent opportunity for a Solo Urologist in Laredo Texas with Enterprise Medical Services
Income guarantee based on the MGMA Guidelines with unlimited earning potential You will receive full support from hospital with state of the art equipment Loan forgiveness, relocation, malpractice and

Urology / Nephrology News From Medical News Today

Adult Male Circumcision Not Linked To Sexual Dysfunction
Wed, 19 Nov 2008 03:00:00 -0800
The World Health Organization recommends male circumcision as an important element in HIV prevention programs, and the procedure is promoted in high-risk heterosexual populations. While the benefits of circumcision are well-documented (they also include reduced rates of urinary tract infection, penile cancer, and cervical cancer and chlamydia in female partners), there remains a concern that adult circumcision may impair sexual function.
Analysis Suggests That Improvements In Kidney Function In Patients Treated With Lipitor Strongly Correlate With A Reduced Risk Of Cardiovascular Event
Wed, 19 Nov 2008 02:00:00 -0800
Improvements in kidney function in patients treated with LIPITOR*® (atorvastatin calcium) were shown to strongly correlate with a reduced risk of major cardiovascular events in patients with pre-existing cardiovascular disease, according to a post hoc sub-analysis of the five-year Treating to New Targets (TNT) study presented on 12 November, 2008 at the Annual Scientific Sessions of the American Heart Association.
XTL Biopharmaceuticals Announces Top-Line Results From The Bicifadine Phase 2b Study For Diabetic Neuropathic Pain
Wed, 19 Nov 2008 00:00:00 -0800
XTL Biopharmaceuticals Ltd. (Nasdaq: XTLB; TASE: XTL) announced the top-line results from the Bicifadine Phase 2b clinical trial for the treatment of diabetic neuropathic pain. The trial's primary objective was to compare the efficacy of two doses of Bicifadine against placebo in reducing pain associated with diabetic neuropathy. The primary endpoint of the study was the reduction in pain score during the course of treatment.

BMC Urology - Latest articles

The influence of high and low levels of estrogen on diurnal urine regulation in young women
Charlotte Graugaard-Jensen, Gitte M. Hvistendahl, Jorgen Frokiaer, Peter Bie and Jens Christian Djurhuus Wed, 19 Nov 2008 00:00:00 -0000
Background: Sex hormones have a pronounced effect on arginine vasopressin (AVP), and therefore on the diurnal water homeostasis. Low and high levels of plasma-estradiol as seen in the follicular phase of the menstrual cycle may therefore alter the diurnal regulation of urine production. Furthermore the structural resemblance of oxytocin to vasopressin has led to speculations about the possible antidiuretic properties of oxytocin under normal physiological conditions. To elucidate the influence of high and low p-estradiol on the regulation of the diurnal urine production, 15 normal menstruating women (21-33 y) underwent two circadian in-patient investigations, both situated in follicular phase. Methods: Admitting the participants solely in the follicular phase resulted in high and low plasma-estradiol whereas plasma-progesterone was similar. Urine and blood samples were taken at predetermined time points to determine plasma AVP, plasma oxytocin, plasma aldosterone, plasma natriuretic peptide (ANP), urinary solute excretions, and urinary excretions of prostaglandin E2 (PGE-2) and aquaporin-2 (AQP-2). Blood pressure was measured every hour. Results: Plasma AVP, plasma aldosterone and plasma ANP were unaffected by the different levels of estradiol. All had marked circadian variations whereas oxytocin did not display any circadian rhythm. High estradiol resulted in lower p-osmolality and p-sodium reflecting a downward resetting of the osmoreceptors. Oxytocin did not correlate with either diuresis or urine osmolality. The diurnal urine production was similar in the two groups as were urine osmolality, excretion of PGE-2 and AQP-2. AQP-2 does not have a circadian rhythm and is not significantly correlated to either AVP or oxytocin under normal physiological conditions. Conclusion: High and low level of estradiol has no influence on the circadian rhythm of AVP or the subsequent urine production. High p-estradiol resets the osmoreceptors for AVP release. Furthermore it appears that oxytocin under normal physiological conditions do not contribute to the overall antidiuretic effect.
GOLPH2 expression in renal cell cancer
Florian R Fritzsche, Mark-Oliver Riener, Manfred Dietel, Holger Moch, Klaus Jung and Glen Kristiansen Tue, 11 Nov 2008 00:00:00 -0000
Background: Renal cell carcinomas (RCC) are among the most common and most lethal genitourinary malignancies. GOLPH2 (golgi phosphoprotein 2, GOLM1) has recently been proposed as a biomarker for hepatocellular and prostate cancer. In this study we analysed the expression patterns and the prognostic and diagnostic value of GOLPH2 in RCC. Methods: GOLPH2 protein expression was analysed by immunohistochemistry in 104 clinically well characterized RCC cases in comparison with matched normal kidney tissue and in association with clinico-pathological parameters. Statistical analyses including Kaplan Meier analyses were performed with SPSS version 15.0. Results: GOLPH2 was highly expressed in normal renal tubules and in almost half of RCC with a statistically significant predominance in the papillary and chromophobe histological subtypes. No other associations with clinico-pathological parameters were detectable. The Kaplan-Meier curves showed a weak trend for unfavourable prognosis of tumours with high GOLPH2 expression, but failed significance. Conclusions: GOLPH2 protein is expressed in normal renal tissue (especially in distal tubular epithelia) and is down-regulated in the majority of clear cell RCC. In papillary and chromophobe RCC GOLPH2 expression is consistently present. In contrast to its diagnostic value in hepatocellular and prostatic carcinomas, a prognostic or diagnostic value of GOLPH2 in RCC appears to be unlikely.
Characterization of prostate cancer detected at repeat biopsy
Takeshi Yuasa, Norihiko Tsuchiya, Teruaki Kumazawa, Takamitsu Inoue, Shintaro Narita, Mitsuru Saito, Yohei Horikawa, Shigeru Satoh and Tomonori Habuchi Mon, 10 Nov 2008 00:00:00 -0000
Background: The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy. Methods: We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure. Results: Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; P = 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups. Conclusions: PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.
Implications of computer tomography measurement in the management of renal tumours
Rahul Mistry, Ramaswamy Manikandan, Penny Williams, Joe Philip, Peter Littler, Christopher S Foster and Keith F Parsons Tue, 04 Nov 2008 00:00:00 -0000
Aim: To compare radiographic measurement and pathological measurement of renal tumours to see if there was a significant difference between the two as this may have implications in the management. Methods: We retrospectively analyzed CT measurements of 106 consecutive patients who underwent either radical or nephron sparing surgery in our institution and compared this to the actual measurement of the surgical specimen. The largest axial measurement was compared as this is the primary consideration before offering either treatment modality. Results: The mean age of the patients was 64 years (range 31-92). There were 76 males and 30 females. The median tumour size was 70 mm (range 16-175) on CT and 65 mm (range 15-90) on pathological measurement. 25 patients had a CT size [less than or equal to] 40mm. CT tended to overestimate the size of tumours in 41 patients, underestimate in 45 and agree with surgical size in 20 patients. Statistically there was no significant difference between the two measurements (p = 0.7, Wilcoxon sign ranked test). When subdivided into tumours less than 40mm (p = 0.7) and more than 4mm (p = 0.09) again there was no statistically significant difference between the two measurements. However in 5(5%) patients who were not offered nephron sparing surgery based on CT findings (size >40mm) the pathological size was [less than or equal to] 40mm (p = <0.001, Fishers Exact test). Pathologically the tumours were classified as renal cell carcinoma (n = 98), angiomyolipoma (3), and oncocytoma (5). Conclusion: CT measurement of renal tumour size correlates well with the actual size of the tumour. However CT does tend to overestimate the size in a small number of patients which may have a bearing on the modality of treatment offered.
RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma
Hossein Tezval, Axel S Merseburger, Ira Matuschek, Stefan Machtens, Markus A Kuczyk and Jürgen Serth Fri, 26 Sep 2008 00:00:00 -0000
Background: Epigenetic silencing of RAS association family 1A (RASSF1A) tumor suppressor gene occurs in various histological subtypes of renal cell carcinoma (RCC) but RASSF1A protein expression in clear cell RCC as well as a possible correlation with clinicopathological parameters of patients has not been analyzed at yet. Methods: 318 primary clear cell carcinomas were analyzed using tissue microarray analysis and immunohistochemistry. Survival analysis was carried out for 187 patients considering a follow-up period of 2–240 month. Results: Expression of RASSF1A was found to be significantly decreased in tumoral cells when compared to normal tubular epithelial cells. RASSF1A immunopositivity was significantly associated with pT stage, group stage and histological grade of tumors and showed a tendency for impaired survival in Kaplan-Meier analysis. Conclusion: While most tumors demonstrate a loss of RASSF1A protein, a subset of tumors was identified to exhibit substantial RASSF1A protein expression and show increased tumor progression. Thus RCC tumorigenesis without depletion of RASSF1A may be associated with an adverse clinical outcome.
Nonoperative management of blunt renal trauma: Is routine early follow-up imaging necessary?
John B Malcolm, Ithaar H Derweesh, Reza Mehrazin, Christopher J DiBlasio, David D Vance, Salil Joshi, Robert W Wake and Robert Gold Wed, 03 Sep 2008 00:00:00 -0000
Background: There is no consensus on the role of routine follow-up imaging during nonoperative management of blunt renal trauma. We reviewed our experience with nonoperative management of blunt renal injuries in order to evaluate the utility of routine early follow-up imaging. Methods: We reviewed all cases of blunt renal injury admitted for nonoperative management at our institution between 1/2002 and 1/2006. Data were compiled from chart review, and clinical outcomes were correlated with CT imaging results. Results: 207 patients were identified (210 renal units). American Association for the Surgery of Trauma (AAST) grades I, II, III, IV, and V were assigned to 35 (16%), 66 (31%), 81 (39%), 26 (13%), and 2 (1%) renal units, respectively. 177 (84%) renal units underwent routine follow-up imaging 24–48 hours after admission. In three cases of grade IV renal injury, a ureteral stent was placed after serial imaging demonstrated persistent extravasation. In no other cases did follow-up imaging independently alter clinical management. There were no urologic complications among cases for which follow-up imaging was not obtained. Conclusion: Routine follow-up imaging is unnecessary for blunt renal injuries of grades I-III. Grade IV renovascular injuries can be followed clinically without routine early follow-up imaging, but urine extravasation necessitates serial imaging to guide management decisions. The volume of grade V renal injuries in this study is not sufficient to support or contest the need for routine follow-up imaging.

Current Opinion in Urology - Current Table Of Contents

Editorial introductions.
Page: viiDOI: 10.1097/MOU.0b013e328317cb2d
Reconstructive urology.
Page: 555DOI: 10.1097/MOU.0b013e328311c9f1Authors: Woodhouse, Christopher
Robotic renal and upper tract reconstruction.
Page: 557DOI: 10.1097/MOU.0b013e32830fe43dAuthors: Hyams, Elias S; Mufarrij, Patrick W; Stifelman, Michael D
Current status of tissue engineering in urology.
Page: 564DOI: 10.1097/MOU.0b013e32830f9402Authors: Wood, Dan a; Southgate, Jennifer b
Salvage surgery for bladder outlet obstruction after prostatectomy or cystectomy.
Page: 570DOI: 10.1097/MOU.0b013e328311c9deAuthors: Westney, Ouida L
The prepuce: preservation and reconstruction.
Page: 575DOI: 10.1097/MOU.0b013e328311c9c2Authors: Haseebuddin, Mohammed; Brandes, Steven B

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